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Literature summary extracted from

  • Monajemi, M.; Woodworth, C.F.; Benkaroun, J.; Grant, M.; Larijani, M.
    Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment (2012), Retrovirology, 9, 35.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.B9 additional information the virion infectivity factor of HIV binds cytoplasmic enzyme marking it for degradation Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.B9 deoxycytosine in single-stranded viral DNA + H2O Homo sapiens
-
 deoxyuridine in single-stranded viral DNA + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.B9 Homo sapiens Q9HC16
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.B9 culture condition:CD4+ cell
-
 Homo sapiens
-
3.5.4.B9 monocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.B9 deoxycytosine in single-stranded viral DNA + H2O
-
 Homo sapiens deoxyuridine in single-stranded viral DNA + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.B9 A3G
-
 Homo sapiens
3.5.4.B9 APOBEC3G
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.5.4.B9 physiological function the enzyme mutates the human immunodeficiency virus (HIV) genome by converting deoxycytidine to deoxyuridine in signature trinucleotides (CCC, TCC) on minus strand viral DNA during reverse transcription. The enzyme restricts viral propagation by degrading or incapacitating the coding ability of the HIV genome. The enzyme contributes to the evasion of adaptive immunity by HIV Homo sapiens